Same kit for PLOS ONE?

Yes—change the portal and article-type rules.

Submit without ethics approval?

Human studies usually require it—missing docs are desk-returned.

Follow live structured-abstract headings (often Background, Methods and Findings, Conclusions). Body is IMRaD.

Journal length—not a conference crop. Figures are often separate uploads at submit.

Human studies need ethics and consent; trials need registration. Name CONSORT/STROBE/PRISMA when the design requires it.

Use plos2015.bst (Vancouver numbers), not CS author–year.

Same kit for PLOS ONE?: Yes—change the portal and article-type rules.
Submit without ethics approval?: Human studies usually require it—missing docs are desk-returned.